業績

論文

2024年

• Thioarylation of 6-amino-2,3,6-trideoxy-D-manno-oct-2-ulosonic acid (IminoKdo): Access to 3,6-disubstituted picolinates and mechanistic insights. Manmode, S., Hussain, N., Marin, O. J. G., Kato, A., Veytia-Bucheli, J. I., Vincent, S. P. Gauthier, C*.
  Chem. Eur. J., 30 (12), e202303904, 2024.

  DOI

• Synthesis of 8-epi-L-swainsonine, related C6 alkylated derivatives and their α-L-rhamnosidase inhibition. Shimadate, Y., Oshima, S., Kasamatsu, N., Yamamoto, S., Taguchi, A., Nash, R. J., Fleet, G. W. J., Okada, T.*, Toyooka, N., Kato, A*.
  Tetrahedron Lett., 139, 155008, 2024.

  DOI

2023年

• Nanomolar β-glucosidase and β-galactosidase inhibition by enantiomeric α-1-C-alkyl-1,4-dideoxy-1,4-imino-arabinitol derivatives. Zi, D., Song, Y.-Y., Lu, T.-T., Kise, M., Kato, A.*, Wang, J.-Z., Jia, Y.-M., Li, Y.-X.*, Fleet, G. W. J., Yu, C.-Y.*
  Eur. J. Med. Chem., 247, 115056, 2023.

  DOI

• Design, synthesis and glycosidase inhibition of DAB derivatives with C-4 peptide and dipeptide branches. Zi, D., Shimadate, Y., Wang, J.-Z., Kato, A.*, Li, Y.-X.*, Jia, Y.-M., Fleet, G. W. J., Yu, C.-Y.*
  Org. Biomol. Chem., 21 (13), 2729-2741, 2023.

  DOI

• Design and synthesis of iso-allo-DNJ and L-isoDALDP derivatives: pursuit of potent and selective inhibitors of α-glucosidase. Yang, L.-F., Zhang, M., Shimadate, Y., Kato, A.*, Hou, T.-Y. L., Li, Y.-X.*, Jia, Y.-M., Fleet, G. W. J., Yu, C.-Y.*
  Org. Biomol. Chem., 21 (16), 3453-3464, 2023.

  DOI

• Synthesis of the purported structure of glyphaeaside C and proposed revisions to the structures of the glyphaeaside alkaloids. Byatt, B.*, Kato, A., Pyne, S.*
  J. Nat. Prod., 86 (5), 1261-1273, 2023.

  DOI

• Design and pharmacological chaperone effects of N-(4’-phenylbutyl)-DAB derivatives targeting the lipophilic pocket of lysosomal acid α-glucosidase. Kato, A.*, Nakagome, I., Kise, M., Yoshimura, K., Tanaka, N.*, Nash, R. J., Fleet, G. W. J., Kobayashie Y., Ikeda, H., Okada, T.*, Toyooka, N.
  J. Med. Chem., 66 (13), 9023-9039, 2023.

  DOI

• Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors. Désiré, J.*, Debbah, Z., Gueyrard, D., Marrot, J., Blériot, Y., Kato, A.*
  Carbohydr. Res., 532, 108903, 2023.

  DOI

2022年

• Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif. Désiré, J.*, Foucart, Q., Poveda, A., Gourlaouen, G., Shimadate, Y., Kise, M., Proceviat, C., Ashmus, R., Vocadlo, D. J., Jiménz-Barbero, J., Kato, A.*, Blériot, Y.*
  Carbohydr. Res., 511, 108491, 2022.

  DOI

• Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors. Bouquet, J., Auberger, N., Ashmus, R., King, D., Bordes, A., Fontelle, N., Nakagawa, S., Madden, Z., Proceviat, C., Kato, A.*, Désiré, J.*, Vocadlo, D. J.*, Blériot, Y.*
  Org. Biomol. Chem., 20 (3), 619-629, 2022.

  DOI

• Divergent synthesis of decahydroquinoline-type poison-frog alkaloids. Takashima, K., Okada, T.*, Kato, A., Yamasaki, Y., Sugouchi, T., Akanuma, S., Kubo, Y., Hosoya, K., Morita, H., Ito, T., Kodama, T., Tanabe, G., Toyooka, N.*
  ChemistrySelect, 7 (5), e202104533, 2022.

  DOI

• 5-C-Branched deoxynojirimycin: Strategy for designing a DNJ-based pharmacological chaperone with nanomolar affinity for Pompe disease. Kato, A.*, Nakagome, I., Kanekiyo, U., Lu, T.-T., Li, Y.-X., Yoshimura, K., Kishida, M., Shinzawa, K., Yoshida, T., Tanaka, N., Jia, Y.-M., Nash, R. J., Fleet, G. W. J., Yu, C.-Yi.*
  J. Med. Chem., 65 (3), 2329-2341, 2022.

  DOI

• Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives. Wang, J.-Z., Cheng, B., Kato, A.*, Kise, M., Shimadate, Y., Jia, Y.-M., Li, Y.-X., Fleet, G.W J., Yu, C.-Yi.*
  Eur. J. Med. Chem., 233, 114230, 2022.

  DOI

• Iminosugar amino acid idoBR1 reduces inflammatory responses in microglia. Olajide, O., Iwuanyanwu, V. U., Banjo, O. W., Kato, A., Penkova, Y. B., Fleet, G. W. J., Nash, R. J.*
  Molecules, 27 (10), 3342, 2022.

  DOI

• Borylated 2,3,4,5-tetrachlorophthalimide and their 2,3,4,5-tetrachlorobenzamide analogues: synthesis, their glycosidase inhibition and anticancer properties in view to boron neutron capture therapy. Campkin, D. M., Shimadate, Y., Bartholomew, B., Bernhardt, P. V., Nash, R. J., Sakoff, J. A., Kato, A., Simone, M. I.*
  Molecules, 27 (11), 3447, 2022.

  DOI

• Diastereoselective synthesis, glycosidase inhibition, and docking study of C-7-fluorinated casuarine and australine derivatives. Li, Y.-X., Wang, J.-Z., Shimadate, Y., Kise, M., Kato, A.*, Jia, Y.-M., Fleet, G.W.J., Yu, C.-Y.*
  J. Org. Chem., 87 (11), 7291–7307, 2022.

  DOI

• trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: pharmacological chaperones for Gaucher disease. Wang, J.-Z., Shimadate, Y., Kise, M., Kato, A.*, Jia, Y.-M., Li, Y.-X.*, Fleet, G. W. J., Yu. C.-Y.*
  Eur. J. Med. Chem., 238, 114499, 2022.

  DOI

• Introduction of C-alkyl branches to L-iminosugars changes their active site binding orientation. Kato, A.*, Nakagome, I., Yoshimura, K., Kanekiyo, U., Kishida, M., Shinzawa, K., Lu, T.-T., Li, Y.-X., Nash, R. J., Fleet, G. W. J., Tanaka, N., Yu, C.-Yi.*
  Org. Biomol. Chem., 20 (36), 7250-7260, 2022.

  DOI

• C-6 Fluorinated casuarines as highly potent and selective amyloglucosidase inhibitors: synthesis and structure-activity relationship study. Li, Y.-X., Wang, J.-Z., Shimadate, Y., Kise, M., Kato, A.*, Jia, Y.-M., Fleet, G. W. J., Yu. C.-Y.*
  Eur. J. Med. Chem., 244, 114852, 2022.

  DOI

• Stable D-xylose ditriflate in divergent syntheses of dihydroxy prolines, pyrrolidines, tetrahydrofuran-2-carboxylic acids, and cyclic sugar β-amino acids. Balo, R., Fernández, A. G., Chopdat, A., Ayadi, S. E., Kato, A., Estévez, R. J., Fleet, G. W. J.*, Estévez. J. C.*
  Org. Biomol. Chem., 20 (47), 9447-9459, 2022.

  DOI

2021年

• Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an aza crown iminosugar structure. Bordes, A., Poveda, A., Fontelle, N., Ardá, A., Guillard, J., Ruan, B., Marrot, J., Imaeda, S., Kato, A., Désiré, J., Xie, J.*, Jiménez-Barbero*, J., Blériot, Y*.
  Carbohydr. Res., 501, 108258, 2021.

  DOI

• Azobenzene derivatives show anti-cancer activity against pancreatic cancer cells only under nutrient starvation conditions via G0/G1 cell cycle arrest. Shinzawa, K., Kageta, D., Nash, R. J., Fleet, G. W. J., Imahori, T., Kato, A*.
  Tetrahedron, 85, 132077, 2021.

  DOI

• Synthesis and structural revision of glyphaeaside C. Byatt, B., Kato, A., Pyne, S.*
  Org. Lett., 23 (10), 4029-4033, 2021.

  DOI

• Iminosugar-C-glycosides work as pharmacological chaperones of NAGLU, a glycosidase involved in MPS IIIB rare disease. Zhu, S., Jagadeesh, Y., Tran, A. T., Imaeda, S., Boraston, A., Alonzi, D. S., Poveda, A., Zhang, Y., Désiré, J., Charollais-Thoenig, J., Demotz, S., Kato, A., Butters, T. D., Jiménez-Barbero, J., Sollogoub, M.*, Blériot, Y.*
  Chem. Eur. J., 27 (44), 11291-11297, 2021.

  DOI

• Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-L-ido-DNJ derivatives. Lu, T.-T., Shimadate, Y., Cheng, B., Kanekiyo, U., Kato, A.*, Wang, J.-Z., Li, Y.-X.*, Jia, Y.-M., Fleet, G.W.J., Yu, C.-Y.*
  Eur. J. Med. Chem., 224 (15), 113716, 2021.

  DOI

• Stereocomplementary synthesis of casuarine and its 6-epi-, 7-epi-, and 6,7-diepi-stereoisomers. Li, Y.-X., Wang, J.-Z., Kato, A.*, Shimadate, Y., Kise, M., Jia, Y.-M., Fleet, G.W.J., Yu, C.-Y.*
  Org. Biomol. Chem., 19 (43), 9410-9420, 2021.

  DOI

2020年

• Hanessian-Hullar reaction in the synthesis of highly substituted trans-3,4-dihydroxypyrrolidines: rhamnulose iminosugar mimics inhibit α-glucosidase. Liu, Z., Yoshihara, A., Jenkinson, S. F., Wormald, M. R., Kelly, C., Heap, J. T., Marqvorsen, M. H. S., Estévez, R. J., Fleet, G. W. J.*, Nakagawa, S., Izumori, K., Nash, R. J., Kato, A.*
  Tetrahedron, 76 (1), 130758, 2020.

  DOI

• Synthesis and glycosidase inhibition of N-substituted derivatives of 1,4-dideoxy-1,4-imino-D-mannitol (DIM). Yang,L.-F., Kinami, K., Kato, A.*, Li, Y.-X., Jia, Y.-M.*, Fleet, G. W. J., Yu, C.-Y.*
  Org. Biomol. Chem., 18 (5), 999-1011, 2020.

  DOI

• Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry disease. Martínez-Bailén, M., Carmona,A. T., Cardona, F., Matassini, C., Goti, A., Kubo, M., Kato, A., Robina, I., Moreno-Vargasa, A. J.*
  Eur. J. Med. Chem., 192, 112173, 2020.

  DOI

• Synthesis of pyrrolidine monocyclic analogues of pochonicine and its stereoisomers: Pursuit of sim-plified structures and potent β‑N‑acetylhexosaminidase inhibition. Yan, X., Shimadate, Y., Kato, A.*, Li, Y.-X., Jia, Y.-M., Fleet, G. W. J., Yu, C.-Y.*
  Molecules, 25 (7), 1498, 2020.

  DOI

• A divergent entry to 1,2,3,9-tetrahydroxyquinolizidines. Okada, T.*, Ozaki, T., Kato, A., Adachi, I., Toyooka, N.*
  Tetrahedron Lett., 61 (25), 152030, 2020.

  DOI

• Strategy for designing selective lysosomal acid α-glucosidase inhibitors : binding orientation and influence on selectivity. Kato, A.*, Nakagome, I., Hata, M., Nash, R. J., Fleet, G. W. J., Natori, Y., Yoshimura, Y., Adachi, I., Hirono, S.
  Molecules, 25 (12), 2843, 2020.

  DOI